This paper reports on progress in the analysis of time-domain optical coherence tomography (OCT) applied to the dimensional metrology of through-silicon vias (TSVs), which are vertical interconnect accesses in silicon, enabling three-dimensional (3D) integration in microelectronics, and estimates the deviations from earlier, simpler models. The considered TSV structures are 1D trenches and circular holes etched into silicon with a large aspect ratio. As a prerequisite for a realistic modeling, we work with spectra obtained from reference interferograms measured at a planar substrate, which fully includes the dispersion of the OCT apparatus. Applying a rigorous modal approach, we estimate the differences ...
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A postdoctoral researcher position is available immediately in the Department of Otolaryngology at the University of Southern California. The principal project will be to develop Optical Coherence Tomography (OCT) systems for functional and morphological imaging in the human ear. The utilization of OCT for imaging in the human ear is a growing field with a range of applications from basic science research to the diagnosis and monitoring of disease. The postdoctoral researcher will work within the lab of Brian Applegate, PhD , but in close collaboration with the group of John Oghalai, MD. They occupy adjacent lab space and are part ...
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Leading OCT Technology Enables Specsavers Optometrists to Provide Unsurpassed Eye Care to Their Patients Topcon Medical Systems (TMS), of Oakland, NJ, USA, a leading provider of diagnostic equipment and software solutions for the eye care industry, and Specsavers, Australia’s #1 optometry practice network, are pleased to announce the installation of the 350th Topcon Maestro Fully Automated OCT/Fundus Camera into Specsavers retail locations across Australia and New Zealand. After careful consideration of several devices, Specsavers chose to incorporate the Maestro OCT into all its locations based on its ease of use, space-saving design, enhanced diagnostic tools and clinical accuracy ...
Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence TomographyRead Full Article
Optical coherence tomography (OCT) has a micro-resolution with a penetration depth of about 2 mm and field of view of about 10 mm. This makes OCT well suited for analyzing the anatomical and internal structural assessment of the middle ear. To study the vibratory motion of the tympanic membrane (TM) and its internal structure, we developed a phase-resolved Doppler OCT system using Kasai’s autocorrelation algorithm. Doppler optical coherence tomography is a powerful imaging tool which can offer the micro-vibratory measurement of the tympanic membrane and obtain the micrometer-resolved cross-sectional images of the sample in real-time. To observe the relative ...
Changes in viscoelastic properties of articular cartilage in early stage of osteoarthritis, as determined by optical coherence tomography-based strain rate tomographyRead Full Article
Background Biomechanical changes in articular cartilage are associated with the onset of osteoarthritis. We developed an optical coherence tomography-based strain rate tomography method: stress relaxation optical coherence straingraphy (SR-OCSA). The purpose of this study was to establish an approach for measuring mechanical properties of articular cartilage using SR-OCSA, and to investigate the distribution of viscoelastic properties of articular cartilage in early osteoarthritis. Methods Anterior cruciate ligament transection surgery was performed on the left knees of 8–9-month-old New Zealand white rabbits. SR-OCSA was used to visualize and measure the viscoelastic properties of articular cartilage via attenuation coefficient of strain rate ...
Postdoc Opening in Coronary Artery, Intravascular OCT Computational Imaging at Case Western Reserve UniversityRead Full Article
We have a postdoctoral opportunity to advance new solutions in cardiovascular and ophthalmological biomedical imaging using machine and deep learning approaches. Projects include mass screening of disease, diagnosis/staging, treatment evaluation, and image guided therapies. A particular opportunity exists in coronary artery intravascular OCT, where we use biomechanical experiments, deep learning. and finite element modeling with the intention of creating software to help plan interventional treatments. Trainees will have an opportunity to join and learn from the wide ranging biomedical imaging community at Case Western Reserve University, which includes the Center of Computational Imaging and Personalized Diagnostics (CCIPD), the Case ...
ZEISS Showcases New CIRRUS 6000 OCT System at the European Society of Retina Specialists 2019 CongressRead Full Article
CIRRUS 6000 at EURETINA ZEISS Showcases New CIRRUS 6000 OCT System at the European Society of Retina Specialists 2019 Congress The ZEISS CIRRUS 6000, 100kHz OCT system promises to dramatically elevate the efficiency of eye care practices. ZEISS Medical Technology Segment expands its *CIRRUS ® — the most trusted Optical Coherence Tomography (OCT) with the launch of its new CIRRUS 6000, 100kHz ultra-fast OCT system that promises to dramatically elevate the efficiency of advanced care practices. CIRRUS 6000 is the latest addition to an already robust portfolio of OCT devices that are designed to meet the needs of all types and levels ...Mentions: Carl Zeiss Meditec
PhD Position at the Center for Medical Physics and Biomedical Engineering – Medical University of ViennaRead Full Article
Position: PhD, Doctoral student in multimodal optical imaging Location: Center for Medical Physics and Biomedical Engineering – Medical University of Vienna Description: The Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna has an immediate opening for a PhD position. The Center for Medical Physics and Biomedical Engineering is located in one of the largest European University hospitals (AKH Vienna) enabling multi-disciplinary innovative, vibrant science from bench to bedside. The research field focuses on the development, design, and realization as well as application of novel biomedical optical imaging technologies. The post will involve developing a novel imaging ...Mentions: Medical University of Vienna
Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular InterventRead Full Article
This consensus document is the second of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near infrared spectroscopy (NIRS)-IVUS. Beyond guidance of stent selection and optimization of deployment, invasive imaging facilitates angiographic interpretation and may guide treatment in acute coronary syndrome. Intravascular imaging can provide additional important diagnostic information when confronted with angiographically ambiguous lesions and allows assessment of plaque morphology enabling identification of vulnerability characteristics. This second document focuses on useful ...
Assessment of simulated osteoporosis in alveolar bone using optical coherence tomography - Del‐Valle - - Journal of BiophotonicsRead Full Article
Osteoporosis is a skeletal disorder that compromises bone resistance and its diagnosis is usually performed using dual energy X‐ray absorptiometry. Thus, the search for efficient diagnostic methods that do not involve the emission of ionizing radiation is necessary. This study proposed to use the Optical Coherence Tomography (OCT) to evaluate osteoporosis in alveolar bone. Osteoporosis lesions is simulated in vitro in porcine bones, and imaging is performed by OCT and micro‐computed tomography (micro‐CT). A developed algorithm is proposed to calculate the optical attenuation coefficient ( μ t ), mean optical attenuation coefficient ( μ t ), integrated reflectivity ( Δ R ) and bone density ( BD ...
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Cylite Pty Ltd, a developer of 3D imaging and measurement systems for Ophthalmology and Optometry announces the successful close of its Series B funding round led by leading Australian VC firm Main Sequence Ventures with participation from existing US and Australian investors. The new funding leverages previous funding, and grants from the Australian government, to build additional manufacturing capacity for Cylite’s Hyperparallel OCT (HP-OCT) platform as well as extend its sales and support networks in Europe and the US. The investment will also support further R&D to provide new diagnostic capabilities for improved outcomes in anterior segment cataract ...Mentions: Cylite
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An optical probe includes an optical source that generates an optical beam that propagates from a proximal end to a distal end of an optical fiber that imparts a transformation of a spatial profile of the optical beam. An optical control device imparts a compensating spatial profile on the optical beam that at least partially compensates for the transformation of the spatial profile of the optical beam imparted by the optical fiber in response to a control signal from a signal processor. A distal optical source generates a calibration light that propagates through the one or more optical waveguides from ...Mentions: Eric A. Swanson
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Recent Articles From Around The Web
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We demonstrate experimentally ghost optical coherence tomography using a broadband incoherent supercontinuum light source with shot-to-shot random spectral fluctuations. The technique is based on ghost imaging in the spectral domain where the object is the spectral interference pattern generated from an optical coherence tomography interferometer in which a physical sample is placed. The axial profile of the sample is obtained from the Fourier transform of the correlation between the spectrally resolved intensity fluctuations of the supercontinuum and the integrated signal measured at the output of the interferometer. The results are in excellent agreement with measurements obtained from a conventional optical ...Mentions: Tampere University of Technology
Optical coherence tomography and multiple sclerosis: Update on clinical application and role in clinical trialsRead Full Article
Optical coherence tomography (OCT) has emerged as a fast, non-invasive, inexpensive, high-resolution imaging technique in multiple sclerosis (MS). Retinal layer quantification by OCT facilitates a ‘window’ into not only local retinal pathology but also global neurodegenerative processes, recognised to be the principal substrates of disability accumulation in MS. While OCT measures in MS have been demonstrated to reflect visual function, inflammatory activity outside of the visual pathways, disability measures including the prediction of disability progression, whole brain atrophy, and the differential neuroprotective effects of disease-modifying therapies, debate continues regarding the clinical utility of OCT in everyday practice. This review presents ...
Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyesRead Full Article
Purpose: To investigate the relationship between laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) measurements of the peripapillary retina and optic nerve head (ONH) in normal eyes and eyes with primary open-angle glaucoma (POAG). Patients and methods: One eye from each of 46 normal subjects and mild and moderate/advanced POAG patients were included. ONH blood flow acquired by LSFG, circumpapillary vessel density (cpVD, a 250 μm-wide elliptical annulus around the optic disc), and intra-papillary vessel density (ipVD, a 1.5×1.5 mm scan field) acquired by OCTA were measured. Their values were compared among normal controls ...
Femtosecond Laser With Integrated Anterior Segment Optical Coherence Tomography As A Tool To Detect PRE-EXISTING Posterior Capsular Dehiscence And Increase Safety In Posterior Polar CataractsRead Full Article
Purpose To determine the efficacy of femtosecond integrated anterior segment optical coherence tomography (ASOCT) for the detection of posterior capsular dehiscence in posterior polar cataracts (PPC). To evaluate the safety of phacoemulsification in these eyes undergoing Femtosecond Laser Assisted Cataract Surgery (FLACS). Setting Centre For Sight Group of Eye Hospitals, a chain of tertiary eye care hospitals in India. Design Prospective, interventional case series Methods The study included eyes with PPC undergoing FLACS using the Catalys femtosecond platform (Optimedica, CA, USA). Real time OCT guidance was utilized to image the posterior capsule (PC), which was then classified as “intact” or ...
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Purpose Measurement of intra-retinal layer thickness using optical coherence tomography (OCT) has become increasingly prominent in multiple sclerosis (MS) research. Nevertheless, the approaches used for determining the mean layer thicknesses vary greatly. Insufficient data exist on the reliability of different thickness estimates, which is crucial for their application in clinical studies. This study addresses this lack by evaluating the repeatability of different thickness estimates. Methods Studies that used intra-retinal layer segmentation of macular OCT scans in patients with MS were retrieved from PubMed. To investigate the repeatability of previously applied layer estimation approaches, we generated datasets of repeating measurements of ...
Assessment of Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography in Patients with Type 2 Diabetes MellitusRead Full Article
Background: Diabetic retinopathy (DR) is the most common ocular complication of diabetes mellitus (DM) and considered one of the leading causes of blindness in developed countries. Diabetic retinopathy is predominantly a microangiopathy in which high glucose levels can make small blood vessels particularly, vulnerable to damage. Objective: The aim of this work was to assess the thickness of peripapillary retinal nerve fiber layer (RNFL) measured by Swept Source optical coherence tomography (SS-OCT) in patients with Type 2 Diabetes Mellitus (DM). Patients and Methods: The study was an observational cross-sectional study. The study was conducted on 40 eyes of diabetic patients ...Mentions: Topcon Medical Systems
Cleveland Clinic Receives NIH Grant for Preparation and Planning for the Prospective Randomized Image-Guided Ophthalmic Surgery Clinical TrialsRead Full Article
Cleveland Clinic Receives a 2019 NIH Grant for $240,00 for Preparation and Planning for the Prospective Randomized Image-Guided Ophthalmic Surgery Clinical Trials. The principal investigator is Justis Ehlers. Below is a summary of the proposed work. Image-guided surgery with intraoperative optical coherence tomography (OCT) has the potential to have a significant impact on surgical efficiency, patient quality-of-life, surgical safety, and overall surgical outcomes in two common surgical vitreoretinal disorders: macular hole and epiretinal membranes. OCT has revolutionized the clinical management of retinal diseases. The high-resolution cross-sectional information that is provided by OCT now is the mainstay for evaluating anatomic ...
Morphological characteristics of ocular toxoplasmosis and its regression pattern on swept-source optical coherence tomography angiography: a case reportRead Full Article
Background To report the successful treatment of ocular toxoplasmosis and present the use of multimodal imaging to describe the changes in ocular toxoplasmic lesions subsequent to treatment. Case presentation A 73-year-old female visited the clinic with decreased visual acuity in the left eye. Fundus examination showed severe vitreous haze with yellow-white infiltrates near the foveal center. Spectral-domain optical coherence tomography (SD-OCT) revealed disorganization of the retinal structure with markedly thickened choroid beneath the active lesion. Highly elevated serum titers of IgG antibodies against Toxoplasma gondii were observed. Topical and systemic steroids with oral Bactrim were administered after a diagnosis of ...Mentions: Seoul National University
Effect of evolocumab therapy on coronary fibrous cap thickness assessed by optical coherence tomography in patients with acute coronary syndromeRead Full Article
Background The addition of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, evolocumab, to statin therapy produced incremental regression of atherosclerotic plaques and a collaborative prevention of cardiovascular events in patients with coronary artery disease. The effect on fibrous-cup thickness, or extension of the atherosclerotic plaque with PCSK9-inhibitor, for several weeks after onset of acute coronary syndrome (ACS) has never been reported. Methods This study aimed to examine the effect of evolocumab on fibrous-cap thickness, as well as the extent of the atherosclerotic plaque, by serial optical coherence tomography (OCT) analysis in patients with ACS. All patients received rosuvastatin 5 ...
In vivo monitoring the dynamic process of acute retinal hemorrhage and repair in zebrafish with spectral‐domain optical coherence tomographyRead Full Article
Retina, the only light sensor in the human eye, is hidden and extremely fragile. Optimized animal models and efficient imaging techniques are very important for the study of retinopathy. In this work, the rapid retinal injury process and the long‐terms retinal repair process were in vivo continuously evaluated with a novel imaging technology spectral‐domain optical coherence tomography (SD‐OCT) in a unique animal model zebrafish. Acute retinal injury was constructed on adult zebrafish by needle injection surgery. SD‐OCT imaging was carried out immediately after the mechanical injury. The retinal hemorrhage, which lasted only 5 seconds, could be ...
The broad spectrum of application of optical coherence tomography angiography to the anterior segment of the eye in inflammatory conditions: a review of the literatureRead Full Article
Background With an increased number of papers on how to interpret optical coherence tomography angiography (OCTA) findings in uveitis, the aim of this review is to assess its efficacy for the quantitative monitoring of structural and functional changes in inflamed conjunctiva and iris vessels in patients with acute anterior uveitis and iris neovascularization. Main body OCTA, currently designed as a retinal vascular imaging system, has been recently adapted for anterior segment and showed good potential for successful imaging of the conjunctiva, the cornea, and the iris. OCTA can successfully delineate corneal vessels with substantial image quality. At the same time ...
Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosisRead Full Article
Subglottic stenosis (SGS) is a challenging disease to diagnose in neonates. Long-range optical coherence tomography (OCT) is an optical imaging modality that has been described to image the subglottis in intubated neonates. A major challenge associated with OCT imaging is the lack of an automated method for image analysis and micrometry of large volumes of data that are acquired with each airway scan (1 to 2 Gb). We developed a tissue segmentation algorithm that identifies, measures, and conducts image analysis on tissue layers within the mucosa and submucosa and compared these automated tissue measurements with manual tracings. We noted small ...
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Background/objectives: The aim of this article was to study the lower punctum parameters in patients with acquired punctal stenosis using spectral-domain anterior segment optical coherence tomography. Subjects/methods: This was a prospective nonrandomized study that included two groups. Group 1 was composed of 32 puncta from 32 subjects (11 males and 21 females, aged 40–62 years) with epiphora and clinically diagnosed punctal stenosis. Group 2 (control group) included 30 puncta from 30 normal subjects (10 males and 20 females, aged 43–63 years). Anterior segment optical coherence tomography was employed to evaluate lower punctum parameters in all subjects ...
Understanding diagnostic disagreement in angle closure assessment between anterior segment optical coherence tomography and gonioscopyRead Full Article
Background/aims Although being a more objective tool for assessment and follow-up of angle closure, reliability studies have reported a moderate diagnostic performance for anterior segment optical coherence tomography (OCT) technologies when comparing with gonioscopy as the reference standard. We aim to determine factors associated with diagnostic disagreement in angle closure when assessed by anterior segment swept source OCT (SS-OCT, CASIA SS-1000; Tomey, Nagoya, Japan) and gonioscopy. Methods Cross-sectional study. A total of 2027 phakic subjects aged ≥50 years, with no relevant previous ophthalmic history, were consecutively recruited from a community polyclinic in Singapore. Gonioscopy and SS-OCT (128 radial scans ...
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Background Optical coherence tomography (OCT) requires intracoronary injection of contrast media to remove blood from the field of view during image acquisition. Contrast injection may cause a temporal increase in intracoronary pressure. The aim of this study was to compare the intracoronary pressure during contrast injection between OCT and coronary angiography . Methods We measured intracoronary pressure by using a pressure guidewire during contrast injection for OCT and angiography in 30 coronary arteries (mean fractional flow reserve = 0.90 ± 0.03). Contrast media was injected into coronary artery through the guiding catheter by using a mechanical injector pump. Results Intracoronary pressure ... See all articles
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Popular Articles This Week
Postdoc Opening in Coronary Artery, Intravascular OCT Computational Imaging at Case Western Reserve University
A Step-Index Silicate Nonlinear Fiber With All Normal Flattened Dispersion for Coherent Supercontinuum
Microperimetry and OCT angiography evaluation of patients with ischemic diabetic macular edema treated with monthly intravitreal bevacizumab: a pilot study
Optical coherence tomography use for estimation of the efficacy of anti VEGF therapy in diabetic retinopathy and diabetic macular edema.
Second-generation drug-eluting absorbable metal scaffold target-lesion revascularization: an optical coherence tomography case series study and literature review
Specsavers Installs the 350th Topcon Maestro Fully Automated OCT
Postdoc Position at the University of Southern California
Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography
Cleveland Clinic Receives NIH Grant for Preparation and Planning for the Prospective Randomized Image-Guided Ophthalmic Surgery Clinical Trials
Anterior Segment Optical Coherence Tomography Is there a Clinical Role in Management of Primary Angle Closure Disease?
Popular Articles This Month
Postdoctoral Associate Position at Duke Vision and Image Processing Laboratory
ZEISS Showcases New CIRRUS 6000 OCT System at the European Society of Retina Specialists 2019 Congress
Northeast Symposium on Biomedical Optics 2019: October 15th, 2019 at MIT in Cambridge, MA
Cylite Announces Series B Funding Round led by Main Sequence Ventures
Optical coherence refraction tomography
Perimeter Medical Imaging Closes Oversubscribed $C4.4M Financing
PhD Position at the Center for Medical Physics and Biomedical Engineering – Medical University of Vienna
IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION
Topcon Launches the Maestro2 with Automated OCTA
PHD POSITION – OPTICAL COHERENCE TOMOGRAPHY ON AGRO-FOOD PRODUCTS
An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.By Joseph A. Izatt
With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.By Stephen A. Boppart
We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.By Guillermo J. Tearney
I’m so proud of the team here at NinePoint,...Our group over the years has really pushed the limits of engineering innovation to help patients. This past year has been especially fruitful, with the clearance and market launch of a first-of-its-kind artificial intelligence technology, and now with the clearance of a pancreatico-biliary application for the Low-Profile Optical Probe. The ability to promote to this new anatomical space really strengthens the platform of the NvisionVLE Imaging System, and continues to build the opportunity for this technology to help patients.By Eman Namati
Imaging is more accurate, helps guide decisions and facilitates tailored therapy, especially in younger heart attack patients who more frequently have plaque erosion or non-atherosclerotic coronary artery disease.By Giulio Guagliumi
We are very pleased with the outcomes of this study, which are the culmination of hard work by 47 physicians across 18 collaborating hospitals...What is further encouraging is that this study was undertaken without key technological improvements that have since been launched commercially. We anticipate that future studies using the Real-time Targeting laser marking feature and our newly launched artificial intelligence software, Intelligent Real-time Image Segmentation, will improve upon these already very positive results. Working together with our commercial partner, Merit Medical, and many of the leading hospitals in the United States, we are ecstatic that this technology continues to have an important and beneficial impact for patients.By Eman Namati
We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.By Xincheng Yao
With the NSTIN plot, the temporal quadrant of the retinal nerve fiber layer is displayed in the center of the B-scan. This portion of the disc is crucial for everyday visual function, and identification of abnormal thinning in this region is essential for managing glaucoma.By Donald C. Hood
Conavi is delighted to receive approval for the clinical use of the Novasight Hybrid System in Canada and are thankful to the many researchers, clinicians, patients, employees and other stakeholders that made this milestone possible.By Brian K. Courtney
- Audrey K. Bowden